Induced splice modulation of pre-mRNAs shows promise to correct aberrant disease transcripts and restore functional protein and thus has therapeutic potential. Duchenne muscular dystrophy (DMD) results from mutations that disrupt the DMD gene open reading frame causing an absence of dystrophin protein. Antisense oligonucleotide (AO)-mediated exon skipping has been shown to restore functional dystrophin in mdx mice and DMD patients treated intramuscularly in two recent phase 1 clinical trials. Critical to the therapeutic success of AO-based treatment will be the ability to deliver AOs systemically to all affected tissues including the heart. Here, we report identification of a series of transduction peptides (Pip5) as AO conjugates for enhanced systemic and particularly cardiac delivery. One of the lead peptide-AO conjugates, Pip5e-AO, showed highly efficient exon skipping and dystrophin production in mdx mice with complete correction of the aberrant DMD transcript in heart, leading to >50% of the normal level of dystrophin in heart. Mechanistic studies indicated that the enhanced activity of Pip5e-phosphorodiamidate morpholino (PMO) is partly explained by more efficient nuclear delivery. Pip5 series derivatives therefore have significant potential for advancing the development of exon skipping therapies for DMD and may have application for enhanced cardiac delivery of other biotherapeutics.
The real fact is surprising that there are actually a few dozen peptide clinics dotted about the major cities of Australia. You will find that each peptide clinic within the country will have very strict policies that have to comply with the requirements of WADA (World Anti Doping Agency). This you may think will inevitably make the buying process an obstacle of problem after problem, wrong! What these rules mean is that by purchasing from any peptide clinic the customer is practically guaranteed a standard of quality with the assurance that he/she will be buying genuine chemicals.
All peptide injections are compounded under strict sterile conditions according to USP 797 Standards. We use peptides obtained from a GMP certified manufacturer which are all over 99% pure and endotoxin tested and proven to be safe. We also perform sterility tests on all peptide preparations supplied which ensures the quality and safety of our products.
Overseas suppliers create websites specifically focused on targeting the Australian peptide market, selling directly to Australian patients, posing as a local vendor. Be wary of these, as we have just covered, the consumer is not protected when the product comes from an offshore supply. Without regulatory control, business goes on as usual regardless, and there is no accountability required for misleading customers.
Peptides Direct are an Australian based retailer in research peptides. Operating out of their main office in Queensland this company have a reputation to be proud of. The quality of their products as well as the helpful and professional advise that’s available from their own in house doctor makes Peptides Direct a unique force and this is what keeps them as a major competitor in their field.
Our customers are forever our highest need. We enthusiastically guarantee to make the greater part of your encounters with our banded together peptide organization is an ensured achievement. By doing this, we realize that we likewise increment our capability of procuring your trust and setting up a long standing and commonly advantageous relationship. We trust that you will allow us to give you the quality items that you require!
Like everything in life, you need to be careful. Too much of a good thing can be bad. Water and oxygen are essential for survival, however in excessive amounts be prepared to have ‘000’ on standby. The same principal is true for any drug or peptide. When used at the recommended dose, clinical trials have proven peptides to be effective with minimal side effects, if any. In addition, the body even has its own natural feedback mechanisms in place to downregulate high levels.
Purchase Peptides was established with the goal of offering the highest quality research products at the lowest prices, allowing us to set an unbeatable standard of excellence. We believe that our clients deserve the best products and the best service. We place a heavy emphasis on care, confidentiality as well as on the purity of our products. Our goal is to ensure that you have the tools required for accurate and effective research. Whether its generic chemicals, custom peptides or high-level proteins, Purchase Peptides allows its customers to obtain such items safely, privately, and conveniently.
While this is a Peptide Clinics Australia review, that doesn’t mean you should feel restricted to use this company alone. If you find a company that offers a good deal for quality products, go for it! We just want to leave our feedback so you know what to expect. For newbies especially, it is always good to be aware of legitimate companies that you can trust for premium products.
Ordered my peptides 8 weeks ago. Received them within 7 working days, and have noticed an incredible change in my lifestyle. I am sleeping better, mood has enhanced at work and i am training a lot longer during my workouts. Very happy with my results and will be using the products again for sure! Customer service was fantastic as they were very knowledgeable and the follow up phone calls were much appreciated.